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KMID : 0362919840020010115
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Journal of the Korean Society for Therapeutic Radiology and Oncology
1984 Volume.2 No. 1 p.115 ~ p.122
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Analysis of Result of Treatment of Ewing’s Sarcoma
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Lee Myung-Za
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Abstract
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Total 125 patients with primary and metastatic Ewing’s sarcoma were treated in various ways between 1963 to 1977.
Patients were divided into 3 groups according to the treatment methods.
Group 1 was nonprotocol patients with or without chemotherapy. Total 58 patients were entered. Group 1 was divided into 2 subgroups. 33 patients were treated locally without chemotherapy and 25 patients were treated with local therapy and nonprotocol chemotherapy.
Group 2 was treated with local therapy and plus T-2 regimen multiagent chemotherapy. 29 patients were entered.
Group 3 was treated with local therapy and T-6 regimen multiagent chemotherapy. 38 patients were entered.
Local treatments for primary tumor were surgery and/or radiation therapy. Radiation dose ranged between 2,000 and 8,000 rad. Patients with pulmonary metastases received bilateral pulmonary RT.
Local recurrence rate was analyzed according to treatment groups and was 16.8%.
Total 15 yr survival was 33% and 8 yr survival of T-6 group was 64.9%.
An analysis of time were pattern of recurrence of each group, and the correlation of with radiation dose with local recurrence done.
This study concluded that intensive multiagent chemotherapy RT and/or surgery (T-6 regimen) reduced distant metastases, and produced significant increase in local control and survival.
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KEYWORD
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